Description

3-(9 H-Fluoren-9-Ylmethoxycarbonylamino)-4-Phenyl-Butyric Acid is a key Fmoc-protected amino acid derivative, essential for the synthesis of complex peptides and peptidomimetics. Its primary value lies in providing a protected backbone for solid-phase peptide synthesis (SPPS), enabling the precise construction of biologically active sequences. This high-purity building block is critically needed by pharmaceutical R&D teams, biotechnology companies, and fine chemical manufacturers developing therapeutic peptides, diagnostic agents, and advanced research compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental Fmoc-protected amino acid building block for the automated synthesis of custom peptides.
• Pharmaceutical Intermediates: Serves as a critical precursor in the production of active pharmaceutical ingredients (APIs) for peptide-based therapeutics.
• Peptidomimetic Research: Used to create modified peptide analogs with enhanced stability, bioavailability, or target specificity for drug discovery programs.
• Bioconjugation: The carboxylic acid moiety allows for conjugation to other molecules, carriers, or surfaces for creating labeled probes or drug delivery systems.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to identify novel bioactive compounds.
• Academic & Institutional Research: A standard reagent for studies in biochemistry, medicinal chemistry, and molecular biology focused on peptide structure and function.

Basic Information

Item	Detail
Product Name	3-(9 H-Fluoren-9-Ylmethoxycarbonylamino)-4-Phenyl-Butyric Acid
CAS No.	282524-78-1
Molecular Formula	C25H23NO4
Molecular Weight	401.46 g/mol
Synonyms	Fmoc-3-amino-4-phenylbutyric acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-amino-4-phenylbutanoic acid; Fmoc-APBA; Fmoc-3-Amino-4-phenylbutyric Acid; N-Fmoc-3-amino-4-phenylbutyric acid; (3S)-3-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}-4-phenylbutanoic acid (for stereoisomers); 3-(Fmoc-amino)-4-phenylbutyric acid
EINECS	Contact for details

Quality Control

Our 3-(9 H-Fluoren-9-Ylmethoxycarbonylamino)-4-Phenyl-Butyric Acid is manufactured under strict quality systems to meet the exacting standards of pharmaceutical development. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric humidity. For long-term storage, consider using desiccant in the storage environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.