Description

2-Chloro-4-(Trifluoromethyl)Benzyl Bromide is a versatile and high-value halogenated benzyl bromide derivative, serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring both chloro and trifluoromethyl substituents, makes it an essential intermediate for introducing specific functional groups and fluorinated motifs into target molecules. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring trifluoromethylated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the chloro and trifluoromethyl groups contribute to biological activity.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic compounds used in electronic displays and organic light-emitting diodes.
• Functional Polymer Modification: Employed to introduce reactive benzyl bromide sites into polymer chains for further functionalization or cross-linking.
• Cross-Coupling Reactions: Acts as an electrophilic partner in various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) to form complex biaryl structures.
• Organic Synthesis Reagent: Utilized in research laboratories for nucleophilic substitution reactions to create new carbon-carbon and carbon-heteroatom bonds.

Basic Information

Product Name	2-Chloro-4-(Trifluoromethyl)Benzyl Bromide
CAS No.	279252-26-5
Molecular Formula	C8H5BrClF3
Molecular Weight	273.48 g/mol
Synonyms	1-(Bromomethyl)-2-chloro-4-(trifluoromethyl)benzene; α-Bromo-2-chloro-α,α,α-trifluoro-p-xylene; (2-Chloro-4-(trifluoromethyl)phenyl)methyl bromide; 2-Chloro-α-(bromomethyl)-4-(trifluoromethyl)toluene; 2-Chloro-4-trifluoromethylbenzyl bromide; 4-Trifluoromethyl-2-chlorobenzyl bromide
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-(Trifluoromethyl)Benzyl Bromide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee consistency and meet the stringent requirements of our global clientele in research and production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	97.0 - 103.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.