Description

Mutolide is a high-purity synthetic organic compound classified as a bioactive lactone derivative with demonstrated utility in pharmaceutical research and agrochemical development. It serves as a critical intermediate for the synthesis of structurally complex molecules targeting kinase inhibition, antimicrobial activity, and plant growth regulation. Research laboratories, contract development and manufacturing organizations (CDMOs), and specialty chemical manufacturers rely on Mutolide CAS NO 277749-34-5 for its reproducible reactivity and stringent batch-to-batch consistency.

Application

• Pharmaceutical R&D: Key building block for kinase inhibitor candidates in oncology and inflammatory disease programs
• Agrochemical synthesis: Intermediate in the production of novel fungicidal and insecticidal lactone-based actives
• Medicinal chemistry: Scaffold for structure–activity relationship (SAR) studies due to its stereochemically defined γ-lactone core
• Chemical biology probes: Used to develop covalent binders for target engagement validation assays
• Custom synthesis services: Preferred substrate for asymmetric catalysis and late-stage functionalization under mild conditions
• Academic research: Reference standard in method development for chiral HPLC and LC-MS/MS quantification

Basic Information

Product Name	Mutolide
CAS No.	277749-34-5
Molecular Formula	C12H17NO3
Molecular Weight	223.27 g/mol
Synonyms	(3R,4R)-3-[(1R)-1-Hydroxyethyl]-4-methyl-2-oxo-1-azabicyclo[2.2.2]octane-6-carboxylic acid lactone; Mutolide; NSC 726189; ML-1; 3-[(1R)-1-Hydroxyethyl]-4-methyl-2-oxo-1-azabicyclo[2.2.2]octane-6-carboxylic acid δ-lactone; (3R,4R)-Mutolide; (3R,4R)-3-[(1R)-1-Hydroxyethyl]-4-methyl-2-oxo-1-azabicyclo[2.2.2]octane-6-carboxylate; AZD-123
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches of Mutolide are tested per ICH Q5 and Q7 guidelines for identity, assay, residual solvents, heavy metals, and enantiomeric purity. Testing includes HPLC, chiral HPLC, IR spectroscopy, and NMR confirmation. The material meets ACS Reagent Grade specifications and is compliant with REACH and FDA requirements for research-use-only intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at 15–25°C in a dry, well-ventilated area. Due to its light-sensitive nature, avoid exposure to ambient or UV light during handling and storage. Keep away from strong oxidizing agents and incompatible materials such as strong acids or organic solvents unless specified in validated protocols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 99.0%
Specific Rotation	[α]²⁵D = +42.5° to +44.5° (c = 1.0 in methanol)
Enantiomeric Excess (ee)	≥ 99.5%
Residual Solvents (GC)	Meets ICH Q3C Class 3 limits
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.