Description

3-Fmoc-Amino-1-Diazo-2-Propanone is a specialized, high-value diazo compound used as a key building block in advanced organic synthesis. This reagent is critical for introducing the reactive diazoacetyl group under mild conditions, enabling the construction of complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and biotechnology industries for the synthesis of novel active pharmaceutical ingredients (APIs), peptide mimetics, and other fine chemicals.

Application

• Peptide Chemistry: As a versatile intermediate for the synthesis of modified peptides and peptidomimetics, particularly for introducing ketone functionalities.
• Pharmaceutical Research: A crucial building block in the development of protease inhibitors, enzyme substrates, and other biologically active compounds.
• Chemical Biology: Used in the preparation of activity-based probes (ABPs) and affinity labels for studying enzyme function and mechanism.
• Material Science: Potential precursor for the synthesis of functionalized polymers and dendrimers with specific reactive handles.
• Cross-coupling Reactions: Serves as a substrate in metal-catalyzed transformations, such as cyclopropanation and X-H insertion reactions.
• Academic Research: Employed in methodological studies exploring new reactions of diazo compounds and carbene chemistry.

Basic Information

Product Name	3-Fmoc-Amino-1-Diazo-2-Propanone
CAS No.	275816-73-4
Molecular Formula	C₁₈H₁₅N₃O₃
Molecular Weight	321.33 g/mol
Synonyms	1-Diazo-3-[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-2-propanone; N-Fmoc-3-amino-1-diazoacetone; 3-[(9-Fluorenylmethyloxycarbonyl)amino]-1-diazoacetone; Fmoc-NH-CH2-CO-CHN2; Fmoc-Amino Diazoacetone; 3-(Fmoc-amino)-1-diazo-2-propanone; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-amino-1-diazoacetone
EINECS	Contact for details

Quality Control

Our 3-Fmoc-Amino-1-Diazo-2-Propanone is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for demanding research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory and quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent decomposition and oxidation. Allow the container to reach room temperature in a desiccator before opening to minimize moisture uptake. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.