Description

3-(2,2,2-Trifluoroethoxy)Propionitrile is a versatile fluorinated nitrile building block, valued for its unique trifluoroethoxy side chain which imparts desirable properties like enhanced lipophilicity and metabolic stability to target molecules. This compound is essential for advanced chemical synthesis, particularly in the development of novel active ingredients. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, especially those targeting central nervous system (CNS) disorders.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides, where the fluorine moiety improves biological activity and environmental persistence.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated components used in electronic displays and organic light-emitting diodes.
• Functional Material Development: Employed in creating specialty polymers and coatings with specific surface properties and chemical resistance.
• Organic Synthesis Building Block: Utilized in various coupling reactions and cyano-ethylation processes to introduce functionalized chains into complex molecules.

Basic Information

Product Name	3-(2,2,2-Trifluoroethoxy)Propionitrile
CAS No.	272128-06-0
Molecular Formula	C5H6F3NO
Molecular Weight	153.10 g/mol
Synonyms	3-(2,2,2-Trifluoroethoxy)propanenitrile; 2,2,2-Trifluoroethyl 2-cyanoethyl ether; 3-(Trifluoroethoxy)propionitrile; Propionitrile, 3-(2,2,2-trifluoroethoxy)-; TFEPN; TFE-PN; β-(2,2,2-Trifluoroethoxy)propionitrile
EINECS	Contact for details

Quality Control

Our 3-(2,2,2-Trifluoroethoxy)Propionitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chromatography (GC/HPLC) and spectroscopy (NMR, IR), to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated place away from heat sources and incompatible materials. Due to its highly volatile nature, keep containers tightly sealed when not in use. Recommended storage temperature: 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.365 - 1.375
Density (20°C)	1.25 - 1.35 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.