Description

(4,7,10-Tris-Benzyloxycarbonylmethyl-1,4,7,10Tetraaza-Cyclododec-1-Yl)-Acetic Acid is a sophisticated macrocyclic chelating agent and a key intermediate in the synthesis of advanced contrast agents for medical imaging. This compound matters because it provides a versatile platform for binding metal ions, particularly gadolinium, with high stability and specificity, which is critical for diagnostic safety and efficacy. It is primarily needed by pharmaceutical R&D teams, fine chemical manufacturers, and diagnostic imaging companies developing next-generation MRI contrast media and targeted radiopharmaceuticals.

Application

• MRI Contrast Agent Precursor: A crucial building block for synthesizing macrocyclic gadolinium-based contrast agents (GBCAs) like Gadobutrol analogs.
• Radiopharmaceutical Development: Serves as a bifunctional chelator for labeling peptides and antibodies with diagnostic or therapeutic radionuclides (e.g., 68Ga, 177Lu).
• Research Chemical: Used in academic and industrial research to study coordination chemistry, metal ion sequestration, and novel ligand design.
• Fine Chemical Intermediate: Employed in the multi-step synthesis of complex, high-value pharmaceutical compounds requiring precise molecular architecture.
• Catalyst Ligand: Potential application as a ligand in homogeneous catalysis for specialized organic transformations.

Basic Information

Product Name	(4,7,10-Tris-Benzyloxycarbonylmethyl-1,4,7,10Tetraaza-Cyclododec-1-Yl)-Acetic Acid
CAS No.	272120-41-9
Molecular Formula	C41H52N4O8
Molecular Weight	728.88 g/mol
Synonyms	DO3A-tris(t-butyl ester) benzyl-protected precursor; 1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic acid, 10-acetic acid, tris(1,1-dimethylethyl) ester, benzyl-protected; Tris-tert-butyl DO3A-Benzyl; 2-[4,7,10-Tris(2-tert-butoxy-2-oxoethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetic acid benzyl ester derivative; Macrocyclic chelator intermediate; Gadolinium chelator precursor; DOTA-tris(tBu) benzyl ester analog
EINECS	Contact for details

Quality Control

Our production of (4,7,10-Tris-Benzyloxycarbonylmethyl-1,4,7,10Tetraaza-Cyclododec-1-Yl)-Acetic Acid adheres to stringent quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity and structural integrity, meeting the exacting standards required for pharmaceutical intermediate applications. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to support your R&D and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed in a desiccated environment when not in use. For long-term storage, consider inert atmosphere conditions to preserve stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.