Description

Cyclohexanone, 2-Fluoro-2-Methyl-5-(1-Methylethyl)-, (2R,5R)- (9Ci) is a high-purity, stereochemically defined fluorinated cyclohexanone derivative, identified by CAS NO 272114-52-0. This compound is valued for its role as a sophisticated chiral building block and intermediate in advanced synthetic chemistry. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, where its specific stereochemistry and fluorine atom are critical for modulating biological activity and physicochemical properties.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS, metabolic, or anti-infective diseases.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, or insecticides, where the fluorine substituent and stereochemistry can enhance efficacy and environmental profile.
• Advanced Material Precursor: Serves as a building block for specialty polymers, liquid crystals, or organic electronic materials requiring specific fluorinated and chiral motifs.
• Asymmetric Catalysis & Ligand Synthesis: Employed in the development of novel chiral catalysts or ligands for enantioselective synthesis in fine chemical production.
• Flavor & Fragrance Intermediate: Potential use in the synthesis of complex, high-value aroma chemicals where the specific molecular structure imparts unique olfactory properties.
• Academic & Contract Research: A valuable reagent for methodological development in organic synthesis and stereochemistry research within university and CRO laboratories.

Basic Information

Product Name	Cyclohexanone, 2-Fluoro-2-Methyl-5-(1-Methylethyl)-, (2R,5R)- (9Ci)
CAS No.	272114-52-0
Molecular Formula	C10H17FO
Molecular Weight	172.24 g/mol
Synonyms	(2R,5R)-2-Fluoro-2-methyl-5-(propan-2-yl)cyclohexan-1-one; (2R,5R)-2-Fluoro-2-methyl-5-isopropylcyclohexanone; (2R,5R)-2-Fluoro-α,α,5-trimethylcyclohexanemethanol; 2-Fluoro-2-methyl-5-(1-methylethyl)cyclohexanone, (2R,5R)-rel-; (-)-trans-2-Fluoro-2-methyl-5-isopropylcyclohexanone; (1R,4R)-4-Fluoro-4-methyl-1-(propan-2-yl)cyclohexan-1-ol (tautomer); Fluorinated Chiral Cyclohexanone Derivative
EINECS	Contact for details

Quality Control

Our Cyclohexanone, 2-Fluoro-2-Methyl-5-(1-Methylethyl)-, (2R,5R)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, identity confirmation by IR and NMR, and quantification of organic impurities, to ensure it meets the exacting standards required for research and process development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, enantiomeric excess, and full analytical data.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. For long-term storage, consider inert gas purging to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.