Description

n-(2-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Acetamide is a high-purity, advanced pharmaceutical intermediate and versatile building block in organic synthesis. Its core value lies in the strategic incorporation of both a protected boronic ester and an acetamide group, enabling efficient cross-coupling reactions and targeted molecular construction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients through Suzuki-Miyaura coupling.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders and oncology.
• Suzuki-Miyaura Cross-Coupling Reagent: The protected boronic ester functionality makes it a crucial reagent for forming carbon-carbon bonds in medicinal chemistry and material science.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Material Science Precursor: Serves as a monomer or precursor for synthesizing advanced organic electronic materials and polymers.
• Chemical Biology Probes: Employed in the creation of labeled compounds and probes for studying biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis services catering to R&D and pilot-scale production.

Basic Information

Product Name	n-(2-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Acetamide
CAS No.	269410-27-7
Molecular Formula	C14H19BFNO3
Molecular Weight	279.12 g/mol
Synonyms	N-[2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetamide; 2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)acetanilide; Acetamide, N-[2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-; 269410-27-7; B- (2-Acetamido-5-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenylacetamide
EINECS	Contact for details

Quality Control

Our n-(2-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Acetamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and structural integrity suitable for sensitive coupling reactions. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.