Description

3-Aminomethylphenylboronic acid pinacol ester is a protected boronic acid derivative, a crucial building block in modern synthetic organic chemistry. Its primary value lies in its dual functionality, combining a reactive amine group with a protected boronate ester, making it an essential intermediate for Suzuki-Miyaura cross-coupling reactions. This compound is particularly vital for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients, as well as in materials science for creating advanced organic electronic materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing complex drug candidates, especially in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides requiring specific aryl-amine architectures.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronate ester coupling partner for constructing biaryl and heterobiaryl structures.
• Materials Science Research: Employed in the synthesis of organic semiconductors, ligands for catalysts, and metal-organic frameworks (MOFs).
• Peptide Modification: Facilitates the site-specific introduction of boronic acid functionality into peptides and biomolecules.
• Chemical Biology Probes: Used to create activity-based probes for studying enzyme function and protein interactions.

Basic Information

Product Name	3-Aminomethylphenylboronic acid pinacol ester
CAS No.	269410-09-5
Molecular Formula	C14H22BNO2
Molecular Weight	247.14 g/mol
Synonyms	(3-(Aminomethyl)phenyl)boronic acid pinacol ester; 3-(Aminomethyl)benzeneboronic acid pinacol ester; 1,3,2-Dioxaborolane, 2-[3-(aminomethyl)phenyl]-4,4,5,5-tetramethyl-; 3-(Boc-aminomethyl)phenylboronic acid pinacol ester (protected form); 3-AMBP; 3-Aminobenzylboronic acid pinacol ester; [3-(Aminomethyl)phenyl]boronic acid pinacol ester; B-(3-(Aminomethyl)phenyl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 3-Aminomethylphenylboronic acid pinacol ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the high standards required for research and commercial synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent batch-to-batch quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.