Description

3-(4-Chloro-2-Fluorophenyl)-3-Oxopropanenitrile is a versatile and high-value fluorinated aromatic intermediate. This compound is critical for the synthesis of complex molecules, particularly in advanced pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists in the fine chemical and pharmaceutical industries for constructing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), especially those containing fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and insecticides, where the chloro-fluorophenyl moiety imparts specific biological activity.
• Material Science Research: Serves as a precursor for specialty polymers, liquid crystals, and organic electronic materials requiring specific fluorinated components.
• Chemical Biology & Proteomics: Employed as a scaffold or labeling agent in the development of molecular probes and enzyme inhibitors.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	3-(4-Chloro-2-Fluorophenyl)-3-Oxopropanenitrile
CAS No.	267880-83-1
Molecular Formula	C9H5ClFNO
Molecular Weight	197.59 g/mol
Synonyms	4-Chloro-2-fluorobenzoylacetonitrile; 2-(4-Chloro-2-fluorobenzoyl)acetonitrile; 3-Oxo-3-(4-chloro-2-fluorophenyl)propanenitrile; 1-(4-Chloro-2-fluorophenyl)-1,3-butanedione nitrile; (4-Chloro-2-fluorobenzoyl)acetonitrile; 4'-Chloro-2'-fluorobenzoylacetonitrile; β-Oxo-4-chloro-2-fluorobenzene propanenitrile
EINECS	Contact for details

Quality Control

We supply 3-(4-Chloro-2-Fluorophenyl)-3-Oxopropanenitrile in high-purity grades suitable for research and commercial synthesis. Our products undergo rigorous quality testing to ensure batch-to-batch consistency and compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.