Description

(2S)-2-[(T-Butoxycarbonyl) Amino]-3-[4-(Dihydroxyboranyl) Phenyl] Propionic Acid is a specialized, high-purity boronic acid derivative featuring a Boc-protected amino acid backbone. This compound matters as a critical building block in modern pharmaceutical research, particularly for the synthesis of proteasome inhibitors and other targeted therapeutics via Suzuki-Miyaura cross-coupling reactions. It is essential for medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and advanced materials sectors who require precise, reliable intermediates for complex organic synthesis.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of bortezomib and other boronic acid-based proteasome inhibitors.
• Suzuki-Miyaura Cross-Coupling: Serves as an organoboron reagent for forming carbon-carbon bonds in complex molecule assembly.
• Peptidomimetic Research: Used to incorporate boronic acid functionality into peptide-like structures for drug discovery.
• Bioconjugation & Probe Development: Enables the creation of targeted molecular probes and bioconjugates for biochemical assays.
• API (Active Pharmaceutical Ingredient) Development: Employed in the research and scale-up stages of novel API synthesis.
• Chemical Biology: Utilized to develop enzyme inhibitors that target serine proteases.

Basic Information

Product Name	(2S)-2-[(T-Butoxycarbonyl) Amino]-3-[4-(Dihydroxyboranyl) Phenyl] Propionic Acid
CAS No.	266999-35-3
Molecular Formula	C14H20BNO6
Molecular Weight	309.13 g/mol
Synonyms	Boc-4-Boronophenylalanine; Boc-Phe(4-B(OH)2)-OH; (S)-2-((tert-Butoxycarbonyl)amino)-3-(4-boronophenyl)propanoic acid; 4-Boronophenylalanine Boc derivative; N-Boc-4-borono-L-phenylalanine; Bortezomib Intermediate; L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-4-borono-; BOC-Phe(4-B(OH)2)-OH
EINECS	Contact for details

Quality Control

Our (2S)-2-[(T-Butoxycarbonyl) Amino]-3-[4-(Dihydroxyboranyl) Phenyl] Propionic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high chemical purity and chiral integrity suitable for pharmaceutical research. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and moisture-sensitive nature. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.