Description

(S)-3-Fmoc-Amino-1-Diazo-5-Methylthio-2-Pentanone is a specialized, high-purity building block used in advanced organic synthesis. This compound is valued for its role as a key intermediate in the synthesis of complex molecules, particularly in pharmaceutical research and development. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for constructing novel peptide mimetics and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly those targeting protease enzymes.
• Peptidomimetic Synthesis: Used to incorporate non-natural amino acid residues and diazo functionalities into peptide backbones for structure-activity relationship (SAR) studies.
• Chemical Biology Probes: Serves as a building block for creating activity-based probes and photoaffinity labels to study enzyme function and protein-protein interactions.
• Combinatorial Chemistry: Employed in solid-phase and solution-phase parallel synthesis libraries for high-throughput screening.
• Academic Research: Utilized in university and institutional labs for methodological development in organic synthesis and medicinal chemistry.
• Process Chemistry Development: Investigated for scalable routes to active pharmaceutical ingredients (APIs) requiring this specific chiral and functionalized scaffold.

Basic Information

Product Name	(S)-3-Fmoc-Amino-1-Diazo-5-Methylthio-2-Pentanone
CAS No.	266359-45-9
Molecular Formula	C₂₂H₂₁N₃O₃S
Molecular Weight	407.49 g/mol
Synonyms	(S)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-1-diazo-5-(methylthio)pentan-2-one; Fmoc-Adp(Mts)-diazoketone; (S)-1-Diazo-3-(N-Fmoc-amino)-5-methylthio-2-pentanone; Fmoc-Asp(OMts)-CHN₂; N-α-Fmoc-L-aspartic acid β-(methylthio) diazomethyl ketone; Fmoc-Asp(Mts)-diazoketone; (S)-3-[(9-Fluorenylmethoxycarbonyl)amino]-1-diazo-5-(methylthio)-2-pentanone
EINECS	Contact for details

Quality Control

Our (S)-3-Fmoc-Amino-1-Diazo-5-Methylthio-2-Pentanone is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems are designed to meet the stringent requirements of pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This compound is light-sensitive and should be handled under subdued lighting. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.