Description

1-3-[3-(Trifluoromethyl)Phenyl]Isoxazol-5-Yl-Ethan-1-One is a high-value fluorinated isoxazole derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in the unique reactivity of the isoxazole ring and the electronic properties imparted by the trifluoromethyl group, enabling the development of novel compounds with enhanced biological activity and material properties. This intermediate is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for creating new active ingredients, as well as by material scientists exploring specialty polymers and electronic chemicals.

Application

• Pharmaceutical Intermediate: Key synthon for the research and development of new drug candidates, particularly in areas targeting central nervous system (CNS) disorders, anti-inflammatory agents, and antimicrobials.
• Agrochemical Active Ingredient Synthesis: Used in constructing novel herbicides, fungicides, and insecticides, leveraging the stability and bioavailability often provided by the trifluoromethyl moiety.
• Material Science Research: Serves as a precursor for specialty polymers, liquid crystals, and organic electronic materials due to its rigid aromatic structure and fluorine content.
• Chemical Biology & Proteomics: Employed as a versatile scaffold or labeling agent in the design of molecular probes and enzyme inhibitors for biochemical research.
• Custom Synthesis & Contract Manufacturing: A vital starting material for fine chemical manufacturers offering bespoke synthesis services for clients in life sciences.

Basic Information

Product Name	1-3-[3-(Trifluoromethyl)Phenyl]Isoxazol-5-Yl-Ethan-1-One
CAS No.	264616-44-6
Molecular Formula	C12H8F3NO2
Molecular Weight	255.19 g/mol
Synonyms	1-[3-[3-(Trifluoromethyl)phenyl]-1,2-oxazol-5-yl]ethanone; 1-(3-(3-(Trifluoromethyl)phenyl)isoxazol-5-yl)ethanone; 5-Acetyl-3-[3-(trifluoromethyl)phenyl]isoxazole; 3'-(Trifluoromethyl)-5-acetylphenylisoxazole; Ethanone, 1-[3-[3-(trifluoromethyl)phenyl]-1,2-oxazol-5-yl]-; CAS 264616-44-6
EINECS	Contact for details

Quality Control

Our production of 1-3-[3-(Trifluoromethyl)Phenyl]Isoxazol-5-Yl-Ethan-1-One adheres to stringent in-process controls and final batch analysis to ensure consistency and high purity. We employ advanced analytical techniques including HPLC, GC, NMR, and MS for comprehensive characterization and impurity profiling. Certificates of Analysis (COA) detailing purity, identity, and specific tests are provided with each shipment, supporting compliance in GMP-aligned synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light) as indicated by its chemical properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.