Description

Carbamic Acid, [(1S,3R,4R)-4-(Hydroxymethyl)Spiro[2.2]Pentyl]-, 1,1- is a high-purity, chiral spirocyclic compound with significant potential in advanced pharmaceutical synthesis. This specialized carbamate derivative is valued for its unique three-dimensional structure, which serves as a critical building block for creating novel, stereochemically defined active pharmaceutical ingredients (APIs). It is primarily targeted at research and development teams, process chemists, and manufacturers in the pharmaceutical and fine chemical industries seeking to develop next-generation therapeutics with improved efficacy and selectivity.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and production of novel small-molecule drugs, particularly in central nervous system (CNS) and antiviral therapeutic areas.
• Protease Inhibitor Development: Utilized as a core scaffold or precursor in the design and synthesis of protease inhibitors due to its carbamate functionality and rigid spiro structure.
• Asymmetric Synthesis: Serves as a sophisticated chiral auxiliary or building block in stereoselective synthesis to introduce complex molecular architecture.
• Medicinal Chemistry Research: Employed in lead optimization and structure-activity relationship (SAR) studies to explore new chemical space and improve drug-like properties.
• Peptidomimetics: Used in the construction of peptidomimetic compounds, where its structure mimics natural peptide turns, enhancing metabolic stability.
• Advanced Material Precursor: Potential application as a monomer or cross-linking agent in the synthesis of specialty polymers with specific chiral or structural properties.

Basic Information

Product Name	Carbamic Acid, [(1S,3R,4R)-4-(Hydroxymethyl)Spiro[2.2]Pentyl]-, 1,1-
CAS No.	263136-79-4
Molecular Formula	C8H13NO3
Molecular Weight	171.19 g/mol
Synonyms	(1S,3R,4R)-4-(Hydroxymethyl)spiro[2.2]pentan-1-yl carbamate; (1S,3R,4R)-4-(Hydroxymethyl)spiro[2.2]pentyl carbamate; 1,1-Carbamic acid, [(1S,3R,4R)-4-(hydroxymethyl)spiro[2.2]pentyl]-; Spiro[2.2]pentane-1-carbamic acid, 4-(hydroxymethyl)-, (1S,3R,4R)-; Chiral Spiro[2.2]pentyl Carbamate Derivative
EINECS	Contact for details

Quality Control

Our production of Carbamic Acid, [(1S,3R,4R)-4-(Hydroxymethyl)Spiro[2.2]Pentyl]-, 1,1- adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity suitable for pharmaceutical research. All materials are manufactured and tested in facilities operating under cGMP principles. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing purity, chiral purity, and impurity profiles as determined by advanced analytical techniques including HPLC, GC, and chiral chromatography.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.