Description

Ethanone, 1-(3-Fluorobicyclo[1.1.1]pent-1-yl)- (9Ci) is a specialized fluorinated ketone building block featuring the unique, rigid bicyclo[1.1.1]pentane (BCP) scaffold. This compound matters for its role in modern medicinal chemistry, where it serves as a valuable intermediate for synthesizing novel drug candidates with improved metabolic stability and physicochemical properties. Pharmaceutical researchers and agrochemical developers need this high-purity intermediate to incorporate the BCP motif, a bioisostere for para-substituted benzene rings, into their target molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) targeting central nervous system (CNS) disorders, metabolic diseases, and oncology.
• Medicinal Chemistry Research: Used in fragment-based drug discovery and lead optimization to explore structure-activity relationships (SAR) by introducing the rigid, three-dimensional BCP core.
• Agrochemical Synthesis: Intermediate in the development of novel herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Material Science Precursor: Potential monomer or cross-linker for developing advanced polymers with specific fluorinated properties.
• Ligand Synthesis for Catalysis: Starting material for creating novel, sterically demanding ligands used in asymmetric catalysis.
• Chemical Biology Probes: Useful for synthesizing molecular probes to study enzyme function and protein-protein interactions.

Basic Information

Item	Details
Product Name	Ethanone, 1-(3-Fluorobicyclo[1.1.1]pent-1-yl)- (9Ci)
CAS No.	262852-00-6
Molecular Formula	C7H9FO
Molecular Weight	128.15 g/mol
Synonyms	1-(3-Fluorobicyclo[1.1.1]pentan-1-yl)ethanone; 3-Fluoro-1-bicyclo[1.1.1]pent-1-ylethanone; 3'-Fluoro-[1,1'-bicyclopentyl]-1-acetone; 3-Fluorobicyclo[1.1.1]pentane-1-acetyl; 1-Acetyl-3-fluorobicyclo[1.1.1]pentane; 3-Fluoro-BCP-acetyl; Fluorinated BCP Ketone; BCP-F-Acetyl
EINECS	Contact for details

Quality Control

Our Ethanone, 1-(3-Fluorobicyclo[1.1.1]pent-1-yl)- (9Ci) is manufactured under strict quality management systems to ensure batch-to-batch consistency for research and development. Each lot undergoes comprehensive analytical characterization, including HPLC purity analysis, NMR and MS for structural confirmation, and residual solvent testing. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.