Description

Bicyclo[1.1.1]pentane-1-carboxylic acid, 3-fluoro-, methyl ester (9Ci) is a high-value, synthetically challenging fluorinated bicyclic building block. This compound is critical for medicinal chemistry and advanced materials research, where its unique three-dimensional, strained [1.1.1]propellane core is used to modulate the physicochemical properties of target molecules. It is primarily sought by pharmaceutical R&D teams and specialty chemical manufacturers for applications in drug discovery, agrochemical development, and the creation of novel polymers.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for incorporating the bioisosteric [1.1.1]propellane motif to improve metabolic stability and membrane permeability.
• Medicinal Chemistry & Drug Discovery: Used as a versatile building block in fragment-based drug design and lead optimization programs to explore novel chemical space.
• Agrochemical Research: Employed in the development of new-generation herbicides, fungicides, and insecticides, where the fluorinated bicyclic structure can enhance biological activity and environmental profile.
• Advanced Material Synthesis: Acts as a monomer or cross-linking agent for creating polymers with unique mechanical, thermal, or optical properties.
• Ligand and Catalyst Development: Utilized in organometallic chemistry to construct sophisticated, three-dimensional ligands for asymmetric catalysis.
• Chemical Biology Probes: Incorporated into molecular probes and tags for studying biological systems and protein-ligand interactions.

Basic Information

Product Name	Bicyclo[1.1.1]pentane-1-carboxylic acid, 3-fluoro-, methyl ester (9Ci)
CAS No.	262851-99-0
Molecular Formula	C8H10FO2
Molecular Weight	157.16 g/mol
Synonyms	3-Fluorobicyclo[1.1.1]pentane-1-carboxylic acid methyl ester; Methyl 3-fluorobicyclo[1.1.1]pentane-1-carboxylate; 3-Fluoro-bicyclo[1.1.1]pentane-1-carboxylic acid methyl ester; Methyl 3-fluorobicyclo[1.1.1]pentanecarboxylate; 3-Fluoro-BCP-methyl ester; 3-Fluoro[1.1.1]propellane-1-methyl carboxylate; 262851-99-0; Methyl 3-fluoro[1.1.1]propellane-1-carboxylate
EINECS	Contact for details

Quality Control

Our Bicyclo[1.1.1]pentane-1-carboxylic acid, 3-fluoro-, methyl ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP and ISO 9001 standards for production, ensuring traceability and consistency for critical R&D and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. For long-term storage, consider inert gas purging to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 95.0% (Area %)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.