Description

3-(Trifluoromethoxy)Phenylboronic Acid, Pinacol Ester is a high-purity, protected boronic acid derivative essential for modern synthetic chemistry. This compound is a critical building block for the Suzuki-Miyaura cross-coupling reaction, enabling the efficient formation of carbon-carbon bonds under mild conditions. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex biaryl and heterobiaryl scaffolds found in active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides containing the trifluoromethoxyphenyl moiety.
• Material Science: Serves as a monomer or cross-linking agent in the development of organic electronic materials, such as OLEDs and semiconductors.
• Ligand & Catalyst Development: Employed in the synthesis of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology & Proteomics: Useful for bioconjugation and as a probe in medicinal chemistry for structure-activity relationship (SAR) studies.
• Custom Synthesis & Contract Manufacturing: A reliable starting material for custom synthesis projects requiring the introduction of the 3-(trifluoromethoxy)phenyl group.

Basic Information

Product Name	3-(Trifluoromethoxy)Phenylboronic Acid, Pinacol Ester
CAS No.	262376-31-8
Molecular Formula	C₁₃H₁₆BF₃O₃
Molecular Weight	288.07 g/mol
Synonyms	3-(Trifluoromethoxy)benzeneboronic acid pinacol ester; 2-[3-(Trifluoromethoxy)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Pinacol [3-(Trifluoromethoxy)phenyl]boronate; 3-(Trifluoromethoxy)phenylboronic acid neopentyl glycol ester (common alternative); 3-(Trifluoromethoxyphenyl)BPin; 3-TFMOPhenyl-BPin; Boronic acid, B-[3-(trifluoromethoxy)phenyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 3-(Trifluoromethoxy)Phenylboronic Acid, Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to ensure high chemical purity and consistent performance in cross-coupling reactions. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every shipment upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent hydrolysis and maintain optimal reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.