Description

(1S,2S,4R)-n-Boc-1-Amino-2-Hydroxycyclopentane-4-Carboxylic Acid Methyl Ester is a high-purity, chiral building block of significant importance in advanced organic synthesis. Its value lies in its defined stereochemistry and protected functional groups, which enable the precise construction of complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for developing novel active pharmaceutical ingredients (APIs) and peptide mimetics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic agents, including protease inhibitors and other small molecule drugs.
• Peptidomimetic Synthesis: Used to introduce constrained cyclopentane scaffolds into peptide chains, enhancing metabolic stability and biological activity.
• Asymmetric Synthesis: Serves as a versatile starting material or intermediate in stereoselective chemical reactions to create other enantiomerically pure compounds.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms and protein-ligand interactions.
• Custom Synthesis & Contract Manufacturing: A critical component for CDMOs (Contract Development and Manufacturing Organizations) working on client-specific, complex organic molecules.

Basic Information

Product Name	(1S,2S,4R)-n-Boc-1-Amino-2-Hydroxycyclopentane-4-Carboxylic Acid Methyl Ester
CAS No.	262280-14-8
Molecular Formula	C₁₃H₂₃NO₅
Molecular Weight	273.32 g/mol
Synonyms	(1S,2S,4R)-1-[(tert-Butoxycarbonyl)amino]-2-hydroxycyclopentane-4-carboxylic acid methyl ester; (1S,2S,4R)-1-(Boc-amino)-2-hydroxycyclopentane-4-carboxylic acid methyl ester; Methyl (1S,2S,4R)-1-(tert-butoxycarbonylamino)-2-hydroxycyclopentane-4-carboxylate; (1S,2S,4R)-Boc-Ahc(2-OH)-OMe; Boc-Ahcp(2-OH)-OMe (stereospecific); tert-Butyl ((1S,2S,4R)-2-hydroxy-4-(methoxycarbonyl)cyclopentyl)carbamate; (1S,2S,4R)-1-N-Boc-amino-2-hydroxycyclopentane-4-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity. Quality is verified through comprehensive analytical techniques including HPLC, chiral HPLC, 1H/13C NMR, and mass spectrometry to confirm identity, stereochemical purity, and chemical purity. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support development and commercial projects requiring compliance with cGMP standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic); ensure the container is sealed under an inert atmosphere after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.