Description

4-(Trifluoromethoxy)-DL-Phenylglycine is a high-purity, non-natural amino acid derivative characterized by its trifluoromethoxy-substituted aromatic ring. This compound is a critical chiral building block and intermediate in advanced organic synthesis, valued for its ability to introduce fluorine-containing motifs that can dramatically alter the physicochemical and metabolic properties of target molecules. It is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, process development, and the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and metabolic disorder targets.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization to incorporate fluorine for improved bioavailability, metabolic stability, and binding affinity.
• Agrochemical Synthesis: Serves as a building block for developing novel herbicides, fungicides, and insecticides where the trifluoromethoxy group enhances biological activity and environmental persistence.
• Peptidomimetics & Bioactive Molecules: Incorporated into peptide analogs and other bioactive compounds to modulate their lipophilicity and receptor interaction profiles.
• Chemical Research: Employed in academic and industrial laboratories for methodological development in asymmetric synthesis and fluorine chemistry.
• Ligand & Catalyst Development: Potential use in the synthesis of specialized ligands for catalysis or diagnostic imaging agents.

Basic Information

Product Name	4-(Trifluoromethoxy)-DL-Phenylglycine
CAS No.	261952-24-3
Molecular Formula	C9H8F3NO3
Molecular Weight	235.16 g/mol
Synonyms	DL-4-(Trifluoromethoxy)phenylglycine; (±)-2-Amino-2-[4-(trifluoromethoxy)phenyl]acetic acid; 4-(Trifluoromethoxy)phenylglycine; α-Amino-4-(trifluoromethoxy)benzeneacetic acid; (RS)-2-Amino-2-(4-trifluoromethoxyphenyl)acetic acid; NSC 759841; DL-4-Trifluoromethoxyphenylglycine
EINECS	Contact for details

Quality Control

Every batch of 4-(Trifluoromethoxy)-DL-Phenylglycine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, typically including parameters such as identity confirmation, chiral purity, assay, and impurity profile. Specifications can be aligned with customer-specific requirements for advanced synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to prevent absorption of atmospheric moisture, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	DL-mixture (Racemic)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.