Description

4-Methoxy-3-(trifluoromethyl)benzonitrile is a versatile trifluoromethylated aromatic nitrile building block, prized for its unique combination of electron-withdrawing groups that impart significant chemical stability and reactivity. This compound is essential for introducing the trifluoromethoxy-substituted phenyl moiety into complex molecular architectures, a key step in developing advanced materials and active pharmaceutical ingredients. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for synthesis and scale-up projects.

Application

• Pharmaceutical Intermediate: A critical synthon for the synthesis of novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) active compound research.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a key precursor for creating fluorinated aromatic cores that improve the dielectric anisotropy and thermal stability of display materials.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Sonogashira) and cyano group transformations to construct complex heterocycles and functionalized arenes.
• Chemical Research & Development: Utilized in academic and industrial labs for exploring new reaction methodologies and creating compound libraries for screening.

Basic Information

Product Name	4-Methoxy-3-(Trifluoromethyl)Benzonitrile
CAS No.	261951-87-5
Molecular Formula	C9H6F3NO
Molecular Weight	201.15 g/mol
Synonyms	3-Trifluoromethyl-4-methoxybenzonitrile; 4-Methoxy-α,α,α-trifluoro-m-toluonitrile; 4-Cyano-2-methoxybenzotrifluoride; 2-Methoxy-5-cyanobenzotrifluoride; 5-Cyano-2-methoxybenzotrifluoride; 4-Methoxy-3-(trifluoromethyl)phenyl cyanide; m-Toluonitrile, 4-methoxy-α,α,α-trifluoro-
EINECS	Contact for details

Quality Control

Our 4-Methoxy-3-(trifluoromethyl)benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids, bases, and oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.