Description

3-Fluoro-4-Methylbenzylamine is a high-purity fluorinated aromatic amine building block essential for advanced organic synthesis. This compound matters for its role as a versatile intermediate in the development of active pharmaceutical ingredients (APIs) and specialty agrochemicals, where its unique fluorine substitution pattern can significantly modulate biological activity and metabolic stability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries seeking to introduce specific fluorinated motifs into complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine atom enhances lipophilicity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer Modification: Employed to introduce functional amine groups into polymer backbones, altering material properties for specialized coatings and adhesives.
• Cross-coupling Reactions: Acts as a substrate in Buchwald-Hartwig amination and other palladium-catalyzed coupling reactions to create complex biaryl amines.
• Peptidomimetics & Bio-conjugation: The benzylamine group is useful for constructing peptide analogs or for bio-conjugation linker chemistry in probe and diagnostic agent development.

Basic Information

Product Name	3-Fluoro-4-Methylbenzylamine
CAS No.	261951-67-1
Molecular Formula	C8H10FN
Molecular Weight	139.17 g/mol
Synonyms	(3-Fluoro-4-methylphenyl)methanamine; 1-(3-Fluoro-4-methylphenyl)methanamine; 3-Fluoro-4-methylbenzenemethanamine; 4-Methyl-3-fluorobenzylamine; α-Amino-3-fluoro-4-methyltoluene; 3-Fluoro-p-tolylmethylamine; 3-Fluoro-4-methyl-benzylamine; 3-Fluoro-4-methylbenzyl amine
EINECS	Contact for details

Quality Control

Our 3-Fluoro-4-Methylbenzylamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by GC-MS, NMR, and IR spectroscopy, to ensure compliance with stringent industry standards. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and batch-to-batch consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This amine is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.