Description

2,4-Dichloro-5-Fluorophenylacetonitrile is a versatile and high-value fluorinated aromatic nitrile building block. This compound is critical for the synthesis of complex molecules, particularly in the pharmaceutical and agrochemical industries, where its unique halogenated structure enables the introduction of key functional groups. It is primarily sought after by research institutions and manufacturers developing active pharmaceutical ingredients (APIs), advanced crop protection agents, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, leveraging the 2,4-dichloro-5-fluoro substitution pattern for enhanced biological activity.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals for high-performance displays.
• Organic Electronics: Employed in the synthesis of electron-deficient units for organic semiconductors and light-emitting materials.
• Cross-Coupling Reactions: The nitrile and halogen groups make it an excellent substrate for Suzuki, Sonogashira, and other palladium-catalyzed cross-coupling reactions.
• Chemical Research & Development: A valuable building block for constructing complex heterocycles and exploring new chemical spaces in medicinal and materials chemistry.

Basic Information

Product Name	2,4-Dichloro-5-Fluorophenylacetonitrile
CAS No.	261763-28-4
Molecular Formula	C8H4Cl2FN
Molecular Weight	204.03 g/mol
Synonyms	(2,4-Dichloro-5-fluorophenyl)acetonitrile; 2-(2,4-Dichloro-5-fluorophenyl)acetonitrile; 2,4-Dichloro-5-fluorobenzyl cyanide; α-Cyano-2,4-dichloro-5-fluorotoluene; 261763-28-4; 2,4-Dichloro-5-fluoro-α-tolunitrile
EINECS	Contact for details

Quality Control

Our 2,4-Dichloro-5-Fluorophenylacetonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.