Description

5-(2-Fluorophenyl)-4H-1,2,4-Triazole-3-Thiol is a high-purity, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in its unique molecular scaffold, which combines a fluorinated aromatic ring with a triazole-thiol functional group, enabling precise modifications in complex molecule development. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries seeking to create novel active ingredients with optimized properties.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in areas like enzyme inhibitors, receptor modulators, and antiviral agents.
• Agrochemical Research: Serves as a precursor in the synthesis of novel herbicides, fungicides, and plant growth regulators, leveraging the bioactivity of the triazole-thiol moiety.
• Material Science: Used in the research of advanced polymers, ligands for metal-organic frameworks (MOFs), and corrosion inhibitors due to its strong coordinating and binding capabilities.
• Chemical Biology & Proteomics: Acts as a versatile handle for bioconjugation and probe development, exploiting the reactivity of the thiol group for labeling proteins and other biomolecules.
• Academic & Contract Research: A valuable reagent for methodological studies in organic chemistry, including heterocyclic synthesis and fluorine chemistry.

Basic Information

Product Name	5-(2-Fluorophenyl)-4H-1,2,4-Triazole-3-Thiol
CAS No.	261633-13-0
Molecular Formula	C8H6FN3S
Molecular Weight	195.22 g/mol
Synonyms	5-(2-Fluorophenyl)-1H-1,2,4-triazole-3-thiol; 5-(2-Fluorophenyl)-4H-1,2,4-triazole-3-thione; 3-Mercapto-5-(2-fluorophenyl)-1,2,4-triazole; 2-Fluorophenyl-1,2,4-triazole-3-thiol; 261633-13-0; 5-(o-Fluorophenyl)-1,2,4-triazole-3-thiol; 5-(2-Fluorophenyl)-3-mercapto-1,2,4-triazole
EINECS	Contact for details

Quality Control

Every batch of 5-(2-Fluorophenyl)-4H-1,2,4-Triazole-3-Thiol is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and development applications. A detailed Certificate of Analysis (COA) confirming identity, purity, and impurity profiles is supplied with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to handle and store the material under an inert atmosphere for long-term stability. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.