Description

(R,E)-4-((tert-Butyldimethylsilyl)Oxy)Pent-2-Enal is a high-value chiral building block and protected aldehyde intermediate used in sophisticated organic synthesis. Its primary value lies in enabling the stereoselective construction of complex molecules, particularly in pharmaceutical research and development. This compound is essential for chemists and manufacturers in the fine chemical, pharmaceutical, and agrochemical industries who require high-purity intermediates for advanced synthetic routes.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of prostaglandins, macrolide antibiotics, and other bioactive molecules.
• Asymmetric Synthesis: Used in stereocontrolled reactions, including aldol additions, nucleophilic additions, and chain extensions, to introduce defined stereocenters.
• Natural Product Synthesis: Serves as a critical precursor in the total synthesis of complex natural products where the (R,E)-configured fragment is required.
• Agrochemical Research: Employed in the development of chiral pesticides and herbicides where specific stereochemistry impacts biological activity.
• Material Science: Potential use as a monomer or precursor for specialized polymers and advanced materials requiring specific functional groups.
• Academic & R&D: A valuable reagent for methodological development in organic chemistry laboratories and for exploring new catalytic processes.

Basic Information

Product Name	(R,E)-4-((tert-Butyldimethylsilyl)Oxy)Pent-2-Enal
CAS No.	260978-54-9
Molecular Formula	C11H22O2Si
Molecular Weight	214.38 g/mol
Synonyms	(R,E)-4-[(tert-Butyldimethylsilyl)oxy]-2-pentenal; (4R)-4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-2-pentenal; (R,E)-4-(tert-Butyldimethylsiloxy)pent-2-enal; (R,E)-TBS-Protected 4-Hydroxypent-2-enal; (R,E)-4-(TBDMSO)Pent-2-enal; (R,E)-4-(tert-Butyldimethylsilyloxy)-2-pentenal; (R,E)-4-O-TBDMS-Pent-2-enal
EINECS	Contact for details

Quality Control

Our (R,E)-4-((tert-Butyldimethylsilyl)Oxy)Pent-2-Enal is produced under strict quality management systems to ensure batch-to-batch consistency and high chemical purity. We employ advanced analytical techniques, including chiral HPLC, GC, and NMR, to verify identity, enantiomeric excess, and impurity profiles. Certificates of Analysis (COA) detailing all specifications are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to maximize stability, as the compound is light-sensitive and may be susceptible to oxidation and moisture over time.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.