Description

3-Chloro-3-(2'-Fluoro[1,1'-Biphenyl]-4-Yl)-2-Methylacrylaldehyde is a high-value, multi-functional chemical intermediate characterized by its unique biphenyl and α,β-unsaturated aldehyde structure. This compound matters for its critical role in the synthesis of complex organic molecules, particularly in advanced pharmaceutical and agrochemical research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially in therapeutic areas requiring complex biphenyl scaffolds.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides, herbicides, and fungicides, leveraging its reactive aldehyde and halogen functionalities.
• Material Science Research: Serves as a precursor for the development of specialty polymers, liquid crystals, and organic electronic materials due to its rigid biphenyl core.
• Organic Synthesis & Catalysis: A versatile reagent in academic and industrial laboratories for constructing complex molecular architectures via reactions like cross-coupling, cyclization, and nucleophilic addition.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	3-Chloro-3-(2'-Fluoro[1,1'-Biphenyl]-4-Yl)-2-Methylacrylaldehyde
CAS No.	259252-07-8
Molecular Formula	C₁₆H₁₂ClFO
Molecular Weight	274.72 g/mol
Synonyms	3-Chloro-3-(2'-fluorobiphenyl-4-yl)-2-methylacrylaldehyde; 2'-Fluoro-4-(3-chloro-2-methyl-1-oxoprop-2-en-1-yl)biphenyl; 3-Chloro-3-(4-(2-fluorophenyl)phenyl)-2-methylpropenal; (E)-3-Chloro-3-(2'-fluoro-[1,1'-biphenyl]-4-yl)-2-methylacrylaldehyde; 259252-07-8; 2-Methyl-3-chloro-3-(2'-fluoro[1,1'-biphenyl]-4-yl)acrylaldehyde
EINECS	Contact for details

Quality Control

Our 3-Chloro-3-(2'-Fluoro[1,1'-Biphenyl]-4-Yl)-2-Methylacrylaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and easily oxidized; for long-term storage, it is recommended to keep the container under an inert atmosphere (e.g., nitrogen or argon) in a desiccator.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.