Description

[3,5-Di(Trifluoromethyl)Phenyl][4-(Trifluoromethoxy)Phenyl]Methanone is a high-value fluorinated aromatic ketone building block, distinguished by its unique trifluoromethyl and trifluoromethoxy substituents. This compound is critical for introducing lipophilicity, metabolic stability, and electron-withdrawing properties into advanced molecular architectures. It is primarily sought after by R&D and process development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and antiviral research programs.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the fluorine motifs enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a core building block for fluorine-containing liquid crystals and organic light-emitting diode (OLED) materials, improving electronic properties and stability.
• Polymer & Specialty Chemicals: Incorporated into high-performance polymers, coatings, and specialty chemicals to impart chemical resistance, low surface energy, and thermal stability.
• Organic Synthesis & Catalysis: Employed as a versatile electrophile or ligand precursor in cross-coupling reactions and organometallic catalysis.
• Material Science Research: Utilized in academic and industrial R&D for developing novel fluorinated organic frameworks and functional materials.

Basic Information

Product Name	[3,5-Di(Trifluoromethyl)Phenyl][4-(Trifluoromethoxy)Phenyl]Methanone
CAS No.	257880-90-3
Molecular Formula	C16H7F9O2
Molecular Weight	402.21 g/mol
Synonyms	3,5-Bis(trifluoromethyl)phenyl 4-(trifluoromethoxy)phenyl ketone; 1-[3,5-Bis(trifluoromethyl)phenyl]-2-[4-(trifluoromethoxy)phenyl]ethanone (common misnomer); [3,5-Bis(trifluoromethyl)phenyl][4-(trifluoromethoxyphenyl)]methanone; α,α,α,α',α',α'-Hexafluoro-3,5-xylyl 4-(trifluoromethoxyphenyl) ketone; (3,5-Bis(trifluoromethyl)phenyl)(4-(trifluoromethoxy)phenyl)methanone; CAS 257880-90-3
EINECS	Contact for details

Quality Control

Our production of [3,5-Di(Trifluoromethyl)Phenyl][4-(Trifluoromethoxy)Phenyl]Methanone adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is fully characterized and undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We support compliance with cGMP, ISO, and REACH standards as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent any potential moisture uptake. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.