Description

5-Methyl-2-Pyridylzinc Bromide is a highly reactive organozinc reagent, specifically a pyridylzinc bromide, widely used in modern synthetic organic chemistry. Its core value lies in enabling efficient and selective carbon-carbon bond formation, particularly in cross-coupling reactions, which are fundamental for constructing complex molecular architectures. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries who require reliable, high-purity building blocks for drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent for introducing the 5-methyl-2-pyridyl moiety into target molecules via Negishi, Kumada, or other transition-metal-catalyzed cross-coupling reactions.
• Agrochemical Active Ingredient Development: Used in the research and production of novel herbicides, fungicides, and insecticides that incorporate substituted pyridine structures.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized pyridine-containing ligands used in homogeneous catalysis.
• Material Science Research: Employed in the creation of organic electronic materials, such as those for OLEDs or conductive polymers, where specific pyridine derivatives are required.
• Academic and R&D Laboratories: A valuable tool for methodological development in organometallic chemistry and for synthesizing complex natural product analogs.
• Scale-up and Process Chemistry: Suitable for use in pilot plant and manufacturing settings where consistent quality and reliable performance of organometallic reagents are critical.

Basic Information

Product Name	5-Methyl-2-Pyridylzinc Bromide
CAS No.	257876-05-4
Molecular Formula	C6H6BrNZn
Molecular Weight	221.42 g/mol
Synonyms	2-(5-Methylpyridin-2-yl)zinc bromide; (5-Methylpyridin-2-yl)zinc bromide; 5-Methyl-2-pyridinezinc bromide; Zinc, bromo(5-methyl-2-pyridinyl)-; 2-Pyridylzinc bromide, 5-methyl-; Bromo(5-methyl-2-pyridinyl)zinc; 5-Methyl-2-pyridylzinc bromide solution
EINECS	Contact for details

Quality Control

Our 5-Methyl-2-Pyridylzinc Bromide is manufactured under stringent quality control protocols to ensure batch-to-batch consistency and high reactivity. Each lot is analyzed to confirm identity, purity, and concentration (typically supplied as a solution in THF or other ethereal solvents). Certificates of Analysis (COA) detailing assay (by titration), solvent content, and impurity profiles are provided and available upon request. Our quality system supports compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C or as specified on the label. This material is hygroscopic (moisture-sensitive) and easily oxidized (store under inert atmosphere). Keep away from heat, sparks, and open flame. Use only in a well-ventilated area or fume hood.

Specification

Item	Specification
Appearance	Clear, colorless to light yellow solution
Identification (IR)	Conforms to structure
Assay (Titration)	0.5 M in THF (or as specified)
Purity (HPLC)	≥ 95% (on anhydrous basis)
Water Content (KF)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.