Description

H-Glu(Ome)-Nh2Hcl is a protected amino acid derivative, specifically the methyl ester hydrochloride salt of glutamine. This compound serves as a crucial building block in peptide synthesis, offering controlled reactivity for the selective formation of peptide bonds. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require high-purity intermediates for drug discovery and development.

Application

• Peptide Synthesis: A key protected intermediate in solid-phase and solution-phase peptide synthesis (SPPS).
• Pharmaceutical Research: Used in the development of novel therapeutic peptides and peptidomimetics.
• Bioconjugation: Serves as a starting material for creating custom linkers and labeled biomolecules.
• Chemical Biology: Employed in the study of protein-protein interactions and enzyme mechanisms.
• API Intermediate: Acts as a critical raw material in the multi-step synthesis of active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in university and institutional labs for fundamental organic and medicinal chemistry studies.

Basic Information

Product Name	H-Glu(Ome)-Nh2Hcl
CAS No.	257288-44-1
Molecular Formula	C6H13N2O3Cl
Molecular Weight	196.63 g/mol
Synonyms	L-Glutamine, N2-methyl ester hydrochloride; H-Gln-OMe·HCl; Fmoc-Gln(Trt)-OH; Glutamine methyl ester hydrochloride; (S)-2-Amino-4-carbamoylbutanoic acid methyl ester hydrochloride; Nα-Boc-Nγ-trityl-L-glutamine; Protected L-glutamine derivative
EINECS	Contact for details

Quality Control

Our H-Glu(Ome)-Nh2Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis to ensure enantiomeric integrity. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, confirming compliance with customer specifications and relevant industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]D20	+15.0° to +20.0° (c=1 in H2O)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.