Description

tert-Butyl 3-(4-Formylphenyl)Azetidine-1-Carboxylate is a versatile and high-value azetidine-based building block, specifically designed for advanced pharmaceutical and fine chemical synthesis. Its core value lies in the strategic combination of a protected amine and a reactive aldehyde functional group, enabling efficient multi-step synthetic routes. This compound is essential for medicinal chemistry researchers and process development chemists in the pharmaceutical industry, serving as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and other complex organic molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Medicinal Chemistry Research: Used extensively in high-throughput screening and structure-activity relationship (SAR) studies to explore new chemical entities.
• Peptidomimetic Synthesis: The azetidine scaffold is valuable for creating conformationally constrained peptide analogs with enhanced metabolic stability and bioavailability.
• Ligand and Catalyst Development: Serves as a building block for constructing novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Custom Synthesis and Contract Manufacturing: A key starting material for custom synthesis projects and the production of specialized fine chemicals on a commercial scale.
• Academic Research: Employed in universities and research institutes for methodological development and exploring new heterocyclic chemistry.

Basic Information

Product Name	tert-Butyl 3-(4-Formylphenyl)Azetidine-1-Carboxylate
CAS No.	253801-18-2
Molecular Formula	C15H19NO3
Molecular Weight	261.32 g/mol
Synonyms	1-Boc-3-(4-formylphenyl)azetidine; 3-(4-Formylphenyl)azetidine-1-carboxylic acid tert-butyl ester; tert-Butyl 3-(4-formylphenyl)azetidine-1-carboxylate; 1-(tert-Butoxycarbonyl)-3-(4-formylphenyl)azetidine; 3-(4-Carboxaldehydephenyl)-1-N-Boc-azetidine; Boc-3-(4-formylphenyl)azetidine; Azetidine-1-carboxylic acid, 3-(4-formylphenyl)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-(4-Formylphenyl)Azetidine-1-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is easily oxidized and should be stored under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.