Description

Ethanone, 1-(5-Amino-2-Methylphenyl)-2,2,2-Trifluoro- (9Ci) is a specialized trifluoromethyl ketone derivative featuring an aromatic amine functional group. This compound is a high-value intermediate prized for its unique trifluoromethyl moiety, which is critical for modulating the physicochemical and metabolic properties of target molecules. It is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of drugs targeting central nervous system (CNS) disorders, anti-inflammatory agents, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science Research: Serves as a precursor for developing specialty polymers, liquid crystals, and organic electronic materials due to its aromatic amine and electron-withdrawing trifluoroacetyl group.
• Chemical Biology & Proteomics: Employed as a reactive handle or scaffold in the design of enzyme inhibitors, activity-based probes, and other chemical tools for biological research.
• Custom Synthesis & Contract Manufacturing: Supplied to fine chemical companies engaged in custom synthesis and scale-up projects for clients in life sciences.

Basic Information

Product Name	Ethanone, 1-(5-Amino-2-Methylphenyl)-2,2,2-Trifluoro- (9Ci)
CAS No.	252580-33-9
Molecular Formula	C9H8F3NO
Molecular Weight	203.16 g/mol
Synonyms	1-(5-Amino-2-methylphenyl)-2,2,2-trifluoroethanone; 2',4'-Diamino-2,2,2-trifluoroacetophenone; 2-Methyl-5-amino-α,α,α-trifluoroacetophenone; 5-Amino-2-methyl-α,α,α-trifluoroacetophenone; 2,2,2-Trifluoro-1-(5-amino-2-methylphenyl)ethanone; Trifluoro(5-amino-2-methylphenyl)methanone; 252580-33-9
EINECS	Contact for details

Quality Control

Our Ethanone, 1-(5-Amino-2-Methylphenyl)-2,2,2-Trifluoro- (9Ci) is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with each shipment, supporting your quality assurance and regulatory compliance needs for research and cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.