Description

(R,S)-Boc-2-Amino-4,4-Difluoro-Butyric Acid is a high-purity, non-natural amino acid derivative featuring a tert-butoxycarbonyl (Boc) protecting group and a difluorinated side chain. This compound is a critical building block in modern pharmaceutical research and development, enabling the synthesis of novel peptide-based therapeutics with enhanced metabolic stability and bioavailability. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the creation of fluorinated peptide analogs and protease inhibitors.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of fluorinated peptide drugs and bioactive molecules.
• Protease Inhibitor Development: Used in the research and production of inhibitors targeting various enzymes like HCV NS3/4A protease.
• Peptidomimetics: Incorporation into peptide backbones to improve stability against enzymatic degradation and alter physicochemical properties.
• Chemical Biology Probes: Serves as a building block for creating fluorinated probes to study protein-protein interactions and enzyme mechanisms.
• Agrochemical Research: Potential intermediate in the development of novel fluorinated active ingredients with improved efficacy.
• Academic & Contract Research: Essential for exploratory chemistry in universities and CROs focused on fluorine chemistry and medicinal chemistry.

Basic Information

Product Name	(R,S)-Boc-2-Amino-4,4-Difluoro-Butyric Acid
CAS No.	252357-43-0
Molecular Formula	C9H15F2NO4
Molecular Weight	239.22 g/mol
Synonyms	Boc-Aad(4,4-F2)-OH; 2-[(tert-Butoxycarbonyl)amino]-4,4-difluorobutanoic Acid; N-Boc-4,4-Difluoronorvaline; N-(tert-Butoxycarbonyl)-4,4-difluoronorvaline; 4,4-Difluoro-N-[(2-methyl-2-propanyl)oxycarbonyl]norvaline; (R,S)-N-Boc-2-Amino-4,4-difluorobutyric Acid; (R,S)-2-((tert-Butoxycarbonyl)amino)-4,4-difluorobutanoic Acid; DL-N-Boc-4,4-Difluoronorvaline
EINECS	Contact for details

Quality Control

Our (R,S)-Boc-2-Amino-4,4-Difluoro-Butyric Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high standards, including cGMP development and non-GMP research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. Keep away from strong acids and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.