Description

Benzeneacetamide, α-Hydroxy-4-(Trifluoromethyl)- is a high-purity, non-natural amino acid derivative characterized by its trifluoromethyl-substituted aromatic ring. This compound is a critical chiral building block and intermediate in advanced organic synthesis, valued for its ability to introduce both fluorinated and hydroxylated motifs into target molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and synthesis of potential drug candidates, particularly in central nervous system (CNS) and metabolic disease therapeutic areas.
• Agrochemical Research: Serves as a precursor in the development of new herbicides and pesticides, where the trifluoromethyl group enhances biological activity and stability.
• Peptidomimetics & Bioactive Molecules: Used to construct non-proteinogenic amino acid residues in peptides and peptide analogs to modulate pharmacokinetic properties.
• Ligand & Catalyst Development: Employed in the synthesis of specialized ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Acts as a monomer or functionalizing agent in the creation of advanced polymers with specific optical or surface properties.
• Chemical Biology Probes: Utilized as a building block for fluorescent tags or activity-based probes to study enzyme function and biological pathways.

Basic Information

Product Name	Benzeneacetamide, α-Hydroxy-4-(Trifluoromethyl)-
CAS No.	251366-96-8
Molecular Formula	C9H8F3NO2
Molecular Weight	219.16 g/mol
Synonyms	2-Amino-2-(4-(trifluoromethyl)phenyl)acetic acid; 4-(Trifluoromethyl)phenylglycine; (4-Trifluoromethylphenyl)glycine; DL-4-(Trifluoromethyl)phenylglycine; α-Amino-4-(trifluoromethyl)benzeneacetic acid; 2-Amino-2-[4-(trifluoromethyl)phenyl]acetic acid; p-Trifluoromethylphenylglycine
EINECS	Contact for details

Quality Control

Our Benzeneacetamide, α-Hydroxy-4-(Trifluoromethyl)- is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity assessment, to ensure it meets the exacting standards required for research and development. A detailed Certificate of Analysis (COA) confirming identity, purity (typically ≥97% by HPLC), and enantiomeric excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee (specify enantiomer)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.