Description

tert-Butyl 4-(4-Amino-2-Fluorophenoxy)Piperidine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a piperidine core with a protected amine and a fluorinated aromatic moiety. This compound is critical for medicinal chemistry research and development, enabling the synthesis of novel drug candidates with enhanced metabolic stability and target selectivity. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of central nervous system (CNS) agents, kinase inhibitors, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) for preclinical and clinical studies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore new chemical entities, particularly for CNS targets and oncology.
• Protease & Kinase Inhibitor Development: Serves as a core scaffold for designing potent inhibitors due to its piperidine and fluorophenoxy structure.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of complex drug molecules under cGMP conditions.
• Chemical Reference Standard: Utilized as a high-purity standard for analytical method development and quality control in API manufacturing.

Basic Information

Product Name	tert-Butyl 4-(4-Amino-2-Fluorophenoxy)Piperidine-1-Carboxylate
CAS No.	250372-00-0
Molecular Formula	C16H23FN2O3
Molecular Weight	310.37 g/mol
Synonyms	1-Boc-4-(4-Amino-2-fluorophenoxy)piperidine; 4-(4-Amino-2-fluorophenoxy)piperidine-1-carboxylic acid tert-butyl ester; tert-Butyl 4-(4-amino-2-fluorophenoxy)-1-piperidinecarboxylate; 1-(tert-Butoxycarbonyl)-4-(4-amino-2-fluorophenoxy)piperidine; 4-(4-Amino-2-fluorophenoxy)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; Boc-4-(4-Amino-2-fluorophenoxy)piperidine; 250372-00-0
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(4-Amino-2-Fluorophenoxy)Piperidine-1-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can adhere to cGMP guidelines for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is easily oxidized and should be stored under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.