Description

2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Methanamine is a high-value boronic ester-protected aniline derivative, serving as a crucial building block in modern synthetic chemistry. Its primary value lies in its dual functionality, combining a protected amine group with a stable pinacol boronate ester, enabling efficient cross-coupling reactions and targeted molecular construction. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity intermediates for complex synthesis.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs) via Suzuki-Miyaura cross-coupling reactions.
• Agrochemical Synthesis: Used in constructing novel herbicide and pesticide molecules that require specific aromatic amine-boronate architectures.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in homogeneous catalysis.
• Material Science Research: Building block for organic electronic materials, such as those used in OLEDs and semiconductors, where precise molecular structure is critical.
• Chemical Biology Probes: Utilized in the development of molecular probes and tags for bio-conjugation and imaging applications.
• Custom Synthesis and R&D: A versatile reagent for contract research organizations (CROs) and academic laboratories exploring new synthetic pathways.

Basic Information

Product Name	2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Methanamine
CAS No.	248274-04-6
Molecular Formula	C13H20BNO2
Molecular Weight	233.11 g/mol
Synonyms	(2-Aminomethylphenyl)boronic acid pinacol ester; 2-(Aminomethyl)phenylboronic acid pinacol ester; 2-(Aminomethyl)benzeneboronic acid pinacol ester; (2-(Aminomethyl)phenyl)boronic acid pinacol ester; 1-[(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanamine; 2-(Aminomethyl)phenylboronic acid, pinacol ester; B-(2-(Aminomethyl)phenyl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Methanamine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports applications requiring high-purity intermediates, including cGMP development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (HPLC, Area %)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.