Description

1-(2-Bromophenyl)-2,2,2-trifluoroethan-1-one is a high-purity, specialized organic building block featuring a brominated phenyl ring and a trifluoroacetyl group. This compound is valued for its unique reactivity profile, serving as a key intermediate in the synthesis of complex molecules, particularly in advanced pharmaceutical and agrochemical research. It is primarily sought by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and material science industries for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing fluorinated motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the bromine atom allows for further functionalization.
• Material Science Research: Serves as a building block for creating advanced organic materials, such as liquid crystals or polymers with specific electronic properties.
• Cross-Coupling Reactions: The aryl bromide moiety makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Heck, or Buchwald-Hartwig aminations.
• Fluorine Chemistry Studies: Employed as a model compound in academic and industrial research to study the effects of the trifluoromethyl ketone group on chemical reactivity and physical properties.
• Ligand and Catalyst Development: Used to synthesize novel chelating ligands or organocatalysts for asymmetric synthesis.

Basic Information

Product Name	1-(2-Bromophenyl)-2,2,2-trifluoroethan-1-one
CAS No.	244229-34-3
Molecular Formula	C8H4BrF3O
Molecular Weight	253.02 g/mol
Synonyms	2-Bromo-α,α,α-trifluoroacetophenone; 2'-Bromo-2,2,2-trifluoroacetophenone; 1-(2-Bromophenyl)-2,2,2-trifluoroethanone; 2-Bromophenyl trifluoromethyl ketone; α,α,α-Trifluoro-2-bromoacetophenone; o-Bromo-α,α,α-trifluoroacetophenone; 2-Bromo-α,α,α-trifluoroacetophenone
EINECS	Contact for details

Quality Control

Our 1-(2-Bromophenyl)-2,2,2-trifluoroethan-1-one is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and scale-up. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems are designed to meet the stringent requirements of our global pharmaceutical and fine chemical partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and potential decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.