Description

Spiro[2.5]Octane-1-Carboxaldehyde, 4-Methylene-, (1R,3R)-Rel- (9Ci) is a high-value, chiral spirocyclic aldehyde building block of significant interest in advanced organic synthesis. Its unique, rigid three-dimensional structure makes it a critical intermediate for constructing complex molecular architectures with precise stereochemistry. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, asymmetric catalysis, and the development of novel active ingredients. CAS No. 244214-77-5.

Application

This specialized chiral aldehyde serves as a versatile precursor in sophisticated chemical synthesis. Key application areas include:

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and antiviral research.
• Asymmetric Synthesis: Used in stereoselective reactions to introduce the spiro[2.5]octane scaffold, a valuable motif for modulating the physicochemical properties of target molecules.
• Ligand and Catalyst Development: Employed in the creation of novel chiral ligands and organocatalysts for enantioselective transformations.
• Agrochemical Research: Serves as an intermediate in the development of new pesticides and herbicides with enhanced efficacy and selectivity.
• Material Science: Potential use in synthesizing specialty polymers and advanced organic materials with unique structural properties.
• Academic & Industrial R&D: A valuable tool for methodological studies and exploring new chemical space in synthetic organic chemistry.

Basic Information

Product Name	Spiro[2.5]Octane-1-Carboxaldehyde, 4-Methylene-, (1R,3R)-Rel- (9Ci)
CAS No.	244214-77-5
Molecular Formula	C10H12O
Molecular Weight	148.20 g/mol
Synonyms	(1R,3R)-rel-4-Methylenespiro[2.5]octane-1-carboxaldehyde; 4-Methylenespiro[2.5]octane-1-carbaldehyde, (1R,3R)-rel-; Spiro[2.5]octane-1-carboxaldehyde, 4-methylene-, (1R,3R)-rel-; (1R,3R)-4-Methylenespiro[2.5]octane-1-carbaldehyde; rel-(1R,3R)-4-Methylenespiro[2.5]octane-1-carboxaldehyde
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity, which is critical for sensitive synthetic applications. Certificates of Analysis (COA) are provided with each shipment, detailing key parameters such as chiral purity, chemical purity, and identity confirmation. We employ advanced analytical techniques including chiral HPLC, GC, NMR, and IR spectroscopy to validate specifications. Quality standards are aligned with cGMP principles where applicable for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C or as specified on the label or COA. This compound is easily oxidized and light-sensitive; prolonged exposure to air, moisture, or light should be avoided to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 95.0% (Typical 97-99%)
Chiral Purity (Chiral HPLC)	≥ 98.0% e.e. (Typical >99%)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.