Description

2'',3'',5''-Trifluoroacetophenone is a specialized fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its value lies in the strategic placement of fluorine atoms on the aromatic ring, which can dramatically influence the electronic properties, metabolic stability, and lipophilicity of target molecules. This compound is primarily sought by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in areas requiring fluorinated motifs for enhanced bioavailability and target binding.
• Agrochemical Synthesis: Used in creating advanced pesticides and herbicides where the trifluoromethyl and ketone functionalities contribute to biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, where fluorine atoms help tune electronic properties and stability.
• Advanced Material Research: Employed in academic and industrial R&D for synthesizing novel fluorinated polymers, ligands for catalysis, and specialty chemicals.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses producing bespoke fluorinated compounds for client projects.

Basic Information

Product Name	2'',3'',5''-Trifluoroacetophenone
CAS No.	243459-93-0
Molecular Formula	C8H5F3O
Molecular Weight	174.12 g/mol
Synonyms	1-(2,3,5-Trifluorophenyl)ethanone; 2,3,5-Trifluoroacetophenone; Ethanone, 1-(2,3,5-trifluorophenyl)-; α,α,α-Trifluoro-o,m,p-tolualdehyde (related); TFAP (abbrev.); Trifluoromethyl phenyl ketone derivative; (2,3,5-Trifluorophenyl)methyl ketone
EINECS	Contact for details

Quality Control

Every batch of 2'',3'',5''-Trifluoroacetophenone is produced and verified under a strict quality management system. We employ advanced analytical techniques including GC, HPLC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment, ensuring full traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.