Description

2'',3'',4''-Trifluoroacetophenone is a high-purity fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. This compound matters as a key intermediate for introducing a trifluoromethyl-substituted phenyl moiety, which is crucial for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Synthesis: Used in the development of new-generation herbicides and fungicides, where the trifluoromethyl group enhances biological activity and environmental persistence.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Acts as a monomer or functionalizing agent in the synthesis of fluorinated polymers and advanced organic electronic materials.
• Chemical Biology Probes: Utilized to create fluorinated analogs of natural products or biomarkers for metabolic pathway studies.

Basic Information

Product Name	2'',3'',4''-Trifluoroacetophenone
CAS No.	243448-15-9
Molecular Formula	C8H5F3O
Molecular Weight	174.12 g/mol
Synonyms	1-(2,3,4-Trifluorophenyl)ethan-1-one; 2,3,4-Trifluoroacetophenone; α,2,3,4-Tetrafluoroacetophenone; 2',3',4'-Trifluoroacetophenone; (2,3,4-Trifluorophenyl)methyl ketone; TFAP (abbrev.); Acetophenone, 2',3',4'-trifluoro-
EINECS	Contact for details

Quality Control

Our 2'',3'',4''-Trifluoroacetophenone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.