Description

4'-Fluoro-3'-(Trifluoromethyl)Propiophenone is a high-value fluorinated aromatic ketone building block, essential for advanced organic synthesis. Its unique trifluoromethyl and fluoro substituents make it a critical intermediate for creating compounds with enhanced metabolic stability and lipophilicity. This product is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers developing novel active ingredients and agrochemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Agrochemical Development: Used to construct advanced active ingredients for herbicides and pesticides, leveraging the fluorine motif for improved efficacy.
• Material Science Research: Serves as a precursor for specialty polymers and liquid crystals where fluorine incorporation modifies physical properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, Grignard additions, and reductive aminations to introduce complex fluorinated aryl groups.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting custom synthesis projects for global clients.

Basic Information

Product Name	4'-Fluoro-3'-(Trifluoromethyl)Propiophenone
CAS No.	239107-27-8
Molecular Formula	C10H8F4O
Molecular Weight	220.16 g/mol
Synonyms	1-(4-Fluoro-3-(trifluoromethyl)phenyl)propan-1-one; 4-Fluoro-3-trifluoromethylpropiophenone; 3'-Trifluoromethyl-4'-fluoropropiophenone; 1-Propanone, 1-[4-fluoro-3-(trifluoromethyl)phenyl]-; Propiophenone, 4'-fluoro-3'-(trifluoromethyl)-; F3C-C6H3(F)-CO-CH2-CH3; 239107-27-8 (CAS); 4-Fluoro-α-ethyl-α-(trifluoromethyl)benzenemethanol (tautomer)
EINECS	Contact for details

Quality Control

Our 4'-Fluoro-3'-(Trifluoromethyl)Propiophenone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, GC for residual solvents, and NMR/IR for structural confirmation, to ensure it meets the stringent requirements of research and development applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and bases. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.