Description

2-(Trifluoromethylthio)Benzyl Bromide is a versatile organobromine building block characterized by the presence of both a benzyl bromide and a trifluoromethylthio (SCF₃) functional group. This compound is highly valued in advanced organic synthesis for its role as an electrophilic reagent, enabling the efficient introduction of the benzyl moiety and the valuable SCF₃ group into target molecules. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly those requiring the incorporation of fluorine-containing motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides where the SCF₃ group can improve lipophilicity and biological activity.
• Material Science Research: Serves as a precursor for synthesizing specialized monomers or ligands used in catalysis and advanced polymer systems.
• Cross-Coupling Reactions: Acts as an electrophilic partner in various metal-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) to form new carbon-carbon bonds.
• Fluorine Chemistry: An essential reagent in medicinal and agrochemical chemistry for introducing the pharmacologically privileged trifluoromethylthio group into lead compounds.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and tags for studying biological processes and target engagement.

Basic Information

Product Name	2-(Trifluoromethylthio)Benzyl Bromide
CAS No.	238403-52-6
Molecular Formula	C₈H₆BrF₃S
Molecular Weight	271.10 g/mol
Synonyms	α-Bromo-2-[(trifluoromethyl)thio]toluene; 1-(Bromomethyl)-2-[(trifluoromethyl)sulfanyl]benzene; 2-(Trifluoromethylthio)benzyl bromide; (2-((Trifluoromethyl)thio)phenyl)methyl bromide; o-(Trifluoromethylthio)benzyl bromide; Benzyl bromide, 2-(trifluoromethylthio)-; Bromomethyl(2-(trifluoromethylthio)phenyl); 2-(SCF3)Benzyl Bromide
EINECS	Contact for details

Quality Control

Our 2-(Trifluoromethylthio)Benzyl Bromide is manufactured under strict quality protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. Due to its light-sensitive nature and reactive benzyl bromide group, containers should be kept sealed under an inert atmosphere when not in use to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.