Description

2',3'-Difluoro-4'-(Trifluoromethyl)Acetophenone is a high-value fluorinated aromatic ketone building block, essential for synthesizing advanced molecules with tailored properties. Its unique trifluoromethyl and difluoro substitution pattern makes it a critical intermediate for introducing lipophilicity and metabolic stability into target compounds. This product is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and central nervous system (CNS) targeted drugs.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the fluorine atoms enhance biological activity and environmental stability.
• Material Science Research: Serves as a precursor for specialty monomers and polymers, contributing to materials with specific optical or electronic properties.
• Liquid Crystal & OLED Development: A valuable intermediate for synthesizing fluorinated components used in display and lighting technologies.
• Cross-Coupling Reactions: Acts as an electrophilic coupling partner in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Fluorine Chemistry Research: An important substrate for studying novel fluorination techniques and the effects of polyfluorination on molecular conformation and reactivity.

Basic Information

Product Name	2',3'-Difluoro-4'-(Trifluoromethyl)Acetophenone
CAS No.	237761-82-9
Molecular Formula	C9H5F5O
Molecular Weight	224.13 g/mol
Synonyms	1-[2,3-Difluoro-4-(trifluoromethyl)phenyl]ethan-1-one; 2,3-Difluoro-4-(trifluoromethyl)acetophenone; 2,3-Difluoro-α,α,α,4-tetramethylacetophenone; 2',3'-Difluoro-4'-trifluoromethylacetophenone; 2,3-Difluoro-4-trifluoromethylacetophenone; 2,3-Difluoro-α,α,α-trifluoro-p-tolyl Methyl Ketone; Ethanone, 1-[2,3-difluoro-4-(trifluoromethyl)phenyl]-
EINECS	Contact for details

Quality Control

Our 2',3'-Difluoro-4'-(Trifluoromethyl)Acetophenone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound should be handled and stored under an inert atmosphere for long-term stability to minimize potential degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.