Description

3'-Fluoro-4'-(trifluoromethyl)acetophenone is a high-purity fluorinated aromatic ketone building block of significant importance in advanced organic synthesis. Its unique structure, featuring both fluorine and trifluoromethyl substituents, makes it a critical intermediate for developing compounds with enhanced metabolic stability, lipophilicity, and bioavailability. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms contribute to improved efficacy and environmental profile.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated components used in electronic display technologies and organic light-emitting diodes.
• Functional Material Development: Employed in creating specialty polymers, coatings, and advanced resins that require specific electronic or surface properties.
• Chemical Research & Development: A versatile scaffold in medicinal and process chemistry for structure-activity relationship (SAR) studies and novel compound library generation.

Basic Information

Item	Details
Product Name	3'-Fluoro-4'-(trifluoromethyl)acetophenone
CAS No.	237761-81-8
Molecular Formula	C9H4F4O
Molecular Weight	204.12 g/mol
Synonyms	1-[3-Fluoro-4-(trifluoromethyl)phenyl]ethanone; 3-Fluoro-4-(trifluoromethyl)acetophenone; 3'-Fluoro-α,α,α,4'-tetramethylacetophenone; 3-Fluoro-4-trifluoromethylacetophenone; 3-Fluoro-4-trifluoromethyl phenyl methyl ketone; 3-Fluoro-4-(trifluoromethyl)phenyl methyl ketone; Ethanone, 1-[3-fluoro-4-(trifluoromethyl)phenyl]-
EINECS	Contact for details

Quality Control

Every batch of 3'-Fluoro-4'-(trifluoromethyl)acetophenone is manufactured under strict quality management systems. We employ advanced analytical techniques, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency meet the exacting standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition. The container should be kept tightly sealed to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.