Description

3'-Fluoro-4'-(trifluoromethyl)propiophenone is a high-purity fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its value lies in the strategic incorporation of both fluorine and a trifluoromethyl group, which are critical for modulating the physicochemical and metabolic properties of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries seeking to develop novel active ingredients with enhanced potency, stability, and bioavailability. The CAS number for this substance is 237761-78-3.

Application

This fluorinated propiophenone derivative serves as a versatile intermediate in sophisticated chemical synthesis. Its primary applications include:

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research, where the fluorine atoms can improve blood-brain barrier penetration and metabolic stability.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group often enhances biological activity and environmental persistence.
• Material Science Precursor: Employed in the synthesis of specialty polymers, liquid crystals, and organic electronic materials that benefit from fluorine's unique electronic and hydrophobic properties.
• Chemical Research & Development: A valuable scaffold for medicinal chemistry programs focused on structure-activity relationship (SAR) studies and lead optimization.
• Fluorine Chemistry Studies: Serves as a model compound for investigating new fluorination methodologies and the behavior of polyfluorinated aromatic systems.

Basic Information

Product Name	3'-Fluoro-4'-(trifluoromethyl)propiophenone
CAS No.	237761-78-3
Molecular Formula	C10H8F4O
Molecular Weight	220.16 g/mol
Synonyms	1-(3-Fluoro-4-(trifluoromethyl)phenyl)propan-1-one; 3-Fluoro-4-trifluoromethylpropiophenone; 1-Propanone, 1-[3-fluoro-4-(trifluoromethyl)phenyl]-; Propiophenone, 3'-fluoro-4'-(trifluoromethyl)-; 3-Fluoro-α-ethyl-4-(trifluoromethyl)benzenemethanol (tautomer); 3-Fluoro-4-trifluoromethyl phenyl ethyl ketone; 3'-Fluoro-4'-trifluoromethyl propiophenone
EINECS	Contact for details

Quality Control

Our 3'-Fluoro-4'-(trifluoromethyl)propiophenone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements of research and process development. Certificates of Analysis (COA) detailing purity (typically by HPLC or GC), identity confirmation (by IR, NMR), and impurity profiles are provided with every shipment. We support compliance with relevant regulatory frameworks for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This compound should be kept separate from strong bases and sources of fluoride ions due to its chemical properties. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.