Description

2-(3-Bromo-5-Chlorophenyl)-1,3-Dioxolane is a high-purity, synthetically valuable organic intermediate characterized by its halogenated aromatic ring protected by an acetal functional group. This compound matters for its role as a versatile building block in advanced organic synthesis, enabling the controlled introduction of a substituted phenyl moiety under mild conditions. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders or possessing halogenated aromatic pharmacophores.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the bromo- and chloro-substituents contribute to biological activity and binding affinity.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in asymmetric catalysis and transition metal complexes.
• Material Science Research: Employed in the synthesis of monomers or functional units for advanced polymers, liquid crystals, or organic electronic materials.
• Cross-Coupling Reactions: The bromo substituent makes it a suitable substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Stille) for carbon-carbon bond formation.
• Protecting Group Strategy: The 1,3-dioxolane group acts as a protecting group for carbonyls, allowing for selective reactions elsewhere on the molecule before deprotection.

Basic Information

Product Name	2-(3-Bromo-5-Chlorophenyl)-1,3-Dioxolane
CAS No.	230642-94-1
Molecular Formula	C9H8BrClO2
Molecular Weight	263.52 g/mol
Synonyms	1,3-Dioxolane, 2-(3-bromo-5-chlorophenyl)-; 2-(3-Bromo-5-chlorophenyl)-1,3-dioxolane; 3-Bromo-5-chlorobenzaldehyde ethylene acetal; (3-Bromo-5-chlorophenyl)-1,3-dioxolane; 3-Bromo-5-chlorobenzaldehyde cyclic ethylene acetal; Benzaldehyde, 3-bromo-5-chloro-, cyclic ethylene acetal; 2-(3-Bromo-5-chloro-phenyl)-[1,3]dioxolane
EINECS	Contact for details

Quality Control

Our 2-(3-Bromo-5-Chlorophenyl)-1,3-Dioxolane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed in a dry environment to prevent hydrolysis of the acetal group. Store away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.