Description

2-Bromo-4-Chloro-1,3-Difluorobenzene is a high-purity, multi-halogenated benzene derivative serving as a critical building block in advanced organic synthesis. Its unique halogen substitution pattern makes it an indispensable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty materials industries for applications such as catalyst ligand synthesis and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring halogenated aromatic cores.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides where the difluoro and bromo/chloro substituents confer specific biological activity.
• Ligand and Catalyst Development: Serves as a versatile scaffold for creating sophisticated ligands used in transition metal catalysis, including cross-coupling reactions.
• Material Science Research: Employed in the synthesis of monomers and polymers for advanced materials, such as liquid crystals and organic semiconductors.
• Fluorine Chemistry Building Block: Utilized in exploratory research to introduce fluorine atoms and other halogens into complex molecular architectures.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects.

Basic Information

Product Name	2-Bromo-4-Chloro-1,3-Difluorobenzene
CAS No.	229180-34-1
Molecular Formula	C6H2BrClF2
Molecular Weight	227.44 g/mol
Synonyms	1-Bromo-3-Chloro-4,6-Difluorobenzene; 3-Chloro-4,6-Difluorobromobenzene; 2-Bromo-4-Chloro-1,3-Difluoro-Benzene; Benzene, 2-bromo-4-chloro-1,3-difluoro-; 4-Chloro-2-bromo-1,3-difluorobenzene
EINECS	Contact for details

Quality Control

Our 2-Bromo-4-Chloro-1,3-Difluorobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.