Description

Benzene, 1-Fluoro-4-[(1R,2R)-2-Methylcyclopropyl]- (9Ci) is a high-purity, chiral fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its unique structural features, combining a fluorine substituent with a stereodefined methylcyclopropyl group, enabling precise modulation of molecular properties in target molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and anti-infectives.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides, where the fluorinated cyclopropyl moiety can enhance biological activity and metabolic stability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and organometallic chemistry.
• Material Science Precursor: Employed in the research of advanced organic electronic materials and liquid crystals due to its specific aromatic and steric profile.
• Chemical Biology Probe Synthesis: Utilized for incorporating fluorine atoms and rigid cyclopropyl structures into molecular probes for studying biological systems.

Basic Information

Product Name	Benzene, 1-Fluoro-4-[(1R,2R)-2-Methylcyclopropyl]- (9Ci)
CAS No.	229168-32-5
Molecular Formula	C10H11F
Molecular Weight	150.19 g/mol
Synonyms	1-Fluoro-4-[(1R,2R)-2-methylcyclopropyl]benzene; (1R,2R)-1-(4-Fluorophenyl)-2-methylcyclopropane; p-[(1R,2R)-2-Methylcyclopropyl]fluorobenzene; (1R,2R)-2-Methyl-1-(4-fluorophenyl)cyclopropane; 4-[(1R,2R)-2-Methylcyclopropyl]fluorobenzene; Fluorinated Chiral Cyclopropylbenzene; (R,R)-1-(4-Fluorophenyl)-2-methylcyclopropane
EINECS	Contact for details

Quality Control

Our Benzene, 1-Fluoro-4-[(1R,2R)-2-Methylcyclopropyl]- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high enantiomeric purity and chemical identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.