Description

Cyclopropanecarbonyl Chloride, 3-[(1Z)-2-Fluoro-1-Propenyl]-2,2-Dimethyl-, (1R,3R)- (9Ci) is a high-purity, stereochemically defined chiral building block of significant interest in advanced organic synthesis. Its core value lies in its unique molecular architecture, featuring a cyclopropane ring, a reactive acid chloride group, and a geometrically defined fluoroalkene moiety, enabling the precise construction of complex molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it serves as a key intermediate for creating novel active ingredients with targeted properties.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of potential drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, metabolic diseases, and anti-infective agents.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides, where the cyclopropane and fluorine motifs can enhance biological activity, stability, and environmental profile.
• Advanced Material Science: Serves as a precursor for specialty monomers and polymers, contributing to materials with specific optical, electronic, or surface properties.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and labeled compounds for studying biological mechanisms and pathways.
• Process Chemistry & Scale-up: Provides a defined starting point for the development of robust, scalable synthetic routes to complex targets in pilot plant and commercial manufacturing.

Basic Information

Product Name	Cyclopropanecarbonyl Chloride, 3-[(1Z)-2-Fluoro-1-Propenyl]-2,2-Dimethyl-, (1R,3R)- (9Ci)
CAS No.	228702-78-1
Molecular Formula	C9H12ClFO
Molecular Weight	190.64 g/mol
Synonyms	(1R,3R)-3-[(1Z)-2-Fluoroprop-1-en-1-yl]-2,2-dimethylcyclopropane-1-carbonyl chloride; (1R,3R)-3-[(Z)-2-Fluoro-1-propenyl]-2,2-dimethylcyclopropanecarbonyl chloride; (1R,3R)-rel-3-[(1Z)-2-Fluoro-1-propen-1-yl]-2,2-dimethylcyclopropanecarboxylic acid chloride; (1R,3R)-3-[(Z)-2-Fluoroprop-1-enyl]-2,2-dimethylcyclopropanecarbonyl chloride; Chiral Fluoroalkene Cyclopropane Carbonyl Chloride
EINECS	Contact for details

Quality Control

Our Cyclopropanecarbonyl Chloride, 3-[(1Z)-2-Fluoro-1-Propenyl]-2,2-Dimethyl-, (1R,3R)- (9Ci) is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for demanding synthetic applications. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature and reactivity as an acid chloride, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent hydrolysis and degradation. Recommended long-term storage temperature is 2-8°C. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.