Description

(2,2-Difluoro-1-Hydroxymethyl-Cyclopropyl)-Methanol is a high-value, multifunctional fluorinated cyclopropane derivative, serving as a critical chiral building block in advanced organic synthesis. Its unique structure, featuring two hydroxymethyl groups on a difluorocyclopropane ring, makes it an essential precursor for creating complex molecules with enhanced biological activity and metabolic stability. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, including potential antiviral and anticancer agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel drug candidates, particularly in antiviral, anticancer, and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the difluorocyclopropane moiety can improve potency and environmental profile.
• Material Science Precursor: Employed in the synthesis of specialty polymers and advanced materials that require fluorinated components for specific chemical resistance or surface properties.
• Ligand and Catalyst Development: Serves as a backbone for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Fluorine Chemistry Research: A valuable compound for academic and industrial research exploring the effects of gem-difluorocyclopropane motifs on molecular conformation and reactivity.

Basic Information

Product Name	(2,2-Difluoro-1-Hydroxymethyl-Cyclopropyl)-Methanol
CAS No.	228580-15-2
Molecular Formula	C6H10F2O2
Molecular Weight	152.14 g/mol
Synonyms	1-(Hydroxymethyl)-2,2-difluorocyclopropanemethanol; 2,2-Difluoro-1-(hydroxymethyl)cyclopropanemethanol; (2,2-Difluorocyclopropane-1,1-diyl)dimethanol; 1,1-Bis(hydroxymethyl)-2,2-difluorocyclopropane; 2,2-Difluorocyclopropane-1,1-dimethanol; DFCP-diol; Gem-Difluorocyclopropanedimethanol
EINECS	Contact for details

Quality Control

Our (2,2-Difluoro-1-Hydroxymethyl-Cyclopropyl)-Methanol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis, to ensure it meets the exacting standards required for pharmaceutical and advanced chemical synthesis. Certificates of Analysis (COA) detailing identity, purity (by HPLC), chiral purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.