Description

(3-Chlorophenylethynyl)Trimethylsilane is a versatile organosilicon building block featuring a terminal alkyne group protected by a trimethylsilyl (TMS) moiety. This compound is critical for advanced organic synthesis, particularly in cross-coupling reactions like the Sonogashira coupling, where it serves as a stable and efficient reagent for introducing the 3-chlorophenylacetylene unit. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, especially those requiring arylacetylene motifs.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the chlorophenyl group confers specific biological activity.
• Material Science & Organic Electronics: Serves as a precursor for conjugated polymers, molecular wires, and organic light-emitting diodes (OLEDs) due to its acetylene functionality.
• Cross-Coupling Reactions: An essential reagent in palladium-catalyzed Sonogashira couplings for carbon-carbon bond formation between sp² and sp carbons.
• Ligand & Catalyst Development: Employed in the preparation of specialized ligands and organometallic catalysts for asymmetric synthesis.
• Chemical Research: A valuable tool in academic and industrial R&D for exploring new synthetic methodologies and constructing complex organic molecules.

Basic Information

Item	Details
Product Name	(3-Chlorophenylethynyl)Trimethylsilane
CAS No.	227936-62-1
Molecular Formula	C11H13ClSi
Molecular Weight	208.76 g/mol
Synonyms	1-Chloro-3-[(trimethylsilyl)ethynyl]benzene; 3-((Trimethylsilyl)ethynyl)chlorobenzene; m-Chlorophenyl(trimethylsilyl)acetylene; (3-Chlorophenyl)ethynyltrimethylsilane; TMS-Protected 3-Chlorophenylacetylene; Trimethyl((3-chlorophenyl)ethynyl)silane; 3-Chlorophenylethynyltrimethylsilane
EINECS	Contact for details

Quality Control

Every batch of (3-Chlorophenylethynyl)Trimethylsilane is produced and tested under strict quality management protocols to ensure consistency and high purity for demanding synthetic applications. Our standard analytical suite includes GC, HPLC, and NMR to verify identity, potency, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.