Description

Ethyl 4-Hydroxy-2-[4-(Trifluoromethyl)Phenyl]-1,3-Thiazole-5-Carboxylate is a high-value, multi-functional heterocyclic building block characterized by its thiazole core and trifluoromethylphenyl substituent. This compound is essential for advanced organic synthesis, offering a versatile scaffold for constructing complex molecules with tailored properties. It is primarily sought after by R&D chemists and process development teams in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-inflammatory agents, and antimicrobials.
• Agrochemical Research: Serves as a core structure for developing new generation herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Material Science: Used in the research and development of advanced organic electronic materials, such as OLED (Organic Light-Emitting Diode) components, due to its electron-deficient aromatic system.
• Chemical Biology Probe: Employed as a building block for creating molecular probes and inhibitors to study enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	Ethyl 4-Hydroxy-2-[4-(Trifluoromethyl)Phenyl]-1,3-Thiazole-5-Carboxylate
CAS No.	227199-08-8
Molecular Formula	C₁₃H₁₀F₃NO₃S
Molecular Weight	317.28 g/mol
Synonyms	5-Carbethoxy-4-hydroxy-2-[4-(trifluoromethyl)phenyl]thiazole; Ethyl 4-hydroxy-2-(4-trifluoromethylphenyl)-1,3-thiazole-5-carboxylate; 4-Hydroxy-2-(4-trifluoromethylphenyl)thiazole-5-carboxylic acid ethyl ester; 2-(4-Trifluoromethylphenyl)-4-hydroxy-1,3-thiazole-5-carboxylic acid ethyl ester; 227199-08-8; Thiazole derivative with trifluoromethylphenyl group.
EINECS	Contact for details

Quality Control

Our Ethyl 4-Hydroxy-2-[4-(Trifluoromethyl)Phenyl]-1,3-Thiazole-5-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide comprehensive Certificates of Analysis (COA) with each shipment to ensure traceability and compliance with your internal specifications and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorinating agents. For long-term storage, consider an inert atmosphere to maximize stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.